Museum of Art and History serves the citizens of Lancaster and the residents of the Antelope Valley through the collection, preservation, exhibition and interpretation of works of art and historical artifacts.

Lancaster is a city located in northern Los Angeles County, California. It is situated in the Antelope Valley and is part of the Greater Los Angeles area. Lancaster is located approximately 70 miles north of downtown Los Angeles. It is bordered by the city of Palmdale to the east and is surrounded by the beautiful landscapes of the Mojave Desert. As of 2019, it had a population of 157,601.

Antelope Valley Indian Museum State Historic Park is California's State Regional Indian Museum representing Great Basin Indian Cultures. The exhibits and interpretive emphasis are on American Indian groups (both aboriginal and contemporary) of the Southwest, Great Basin, and California culture regions, since Antelope Valley was a major prehistoric trade corridor linking all three of these culture regions.