Brazoria County is a county in the U.S. state of Texas. As of the 2020 census, the population of the county was 372,031. The county seat is Angleton. Brazoria County, on the prairie of the Gulf Coast at the mouth of the Brazos River in Southeast Texas, is bordered by Matagorda, Fort Bend, Harris, and Galveston counties. It covers an area of 1,407 square miles. Its highest altitude, Damon Mound, is 146 feet above sea level.